Drug Discoveries & Therapeutics

A one-paragraph abstractconsisting of no more than 250words must be included. It shouldstate the purpose of the study, basicprocedures used, main findings, andconclusions. Abbreviations. All nonstandardabbreviations must be listed inalphabetical order, giving eachabbrevia t ion fo l lowed by i t sspelled-out version. Spell out theterm upon first mention and followit with the abbreviated form inparentheses. Thereafter, use theabbreviated form. Introduction. The introductionshould be a concise statement of thebasis for the study and its scientificcontext.Materials and Methods. Subsectionsunder this heading should includesufficient instruction to replicateexperiments, but well-establishedprotocols may be simply referenced.Drug Discoveries & Therapeuticsendorses the principles of theDeclaration of Helsinki and expectsthat all research involving humanswi l l have been conducted inaccordance with these principles.All laboratory animal studiesmust be approved by the authors’Institutional Review Board(s). Resul t s . The resu l t s sec t ionshould provide details of all ofthe experiments that are requiredto support the conclusions of thepaper. If necessary, subheadingsm a y b e u s e d f o r a n o r d e r l ypresentation. All figures, tables, andphotographs must be referred in thetext. Discussion. The discussion shouldinclude conclusions derived fromthe study and supported by the data.Consideration should be given tothe impact that these conclusionshave on the body of knowledgein which context the experimentswere conducted. In Brief Reports,Results and Discussion sectionsmust be combined. Acknowledgments. All fundingsources should be credited in theAcknowledgments section. Inaddition, people who contributedto the work but who do not fit thecriteria for authors should be listedalong with their contributions. References. References should benumbered in the order in which theyappear in the text. Cite references intext using a number in parentheses.Citing of unpublished results andpersonal communications in thereference list is not recommendedbut these sources may be mentionedin the text. For all references, list allauthors, but if there are more thanfifteen authors, list the first threeauthors and add “et al.” Abbreviatejournal names as they appear inPubMed. Web references can beincluded in the reference list. Example 1:H a m a m o t o H , K a m u r a K ,Razanajatovo IM, Murakami K,Santa T, Sekimizu K. Effects ofmolecular mass and hydrophobicityon transport rates through non-specific pathways of the silkworm larva midgut. Int J AntimicrobAgents 2005; 26:38-42. Example 2:Mizuochi T. Microscale sequencingof N-linked oligosacchaides ofglycoproteins using hydrazinolysis,B io -Ge l P -4 , and sequen t i a lexoglycosidase digestion. In:Methods in Molecular Biology:Vol. 14 Glycoprotein analysis inbiomedicine (Hounsell T, ed.).Humana Press, Totowa, NJ, USA,1993; pp. 55-68. Example 3:Drug Discoveries & Therapeutics.Hot topics & news: China-JapanM e d i c a l Wo r k s h o p o n D r u gDiscoveries and Therapeutics2007. ht tp: / /www.ddt journal .com/hotnews.php (accessed July 1,2007). Figure legends. Include a short titleand a short explanation. Methodsdescribed in detail in the Materialsand me thods s ec t i on shou ldnot be repeated in the legend.Symbols used in the figure mustbe explained. The number of datapoints represented in a graph mustbe indicated. Tables. All tables should have aconcise title and be typed double-spaced on pages separate fromthe text. Do not use vertical rules.Tables should be numbered withRoman numerals consecutively inaccordance with their appearancein the text. Place footnotes to tablesbelow the table body and indicatethem with lowercase superscriptletters. Language editing. Manuscriptssubmi t t ed by au thor s whoseprimary language is not Englishshould have their work proofreadby a native English speaker beforesubmission. The Editing SupportOrganization can provide Englishproofreading, Japanese-Englishtranslation, and Chinese-Englishtranslation services to authorswho want to publish in DrugDiscoveries & Therapeutics andneed assistance before submittingan article. Authors can contact thisorganization directly at http://www.iacmhr.com/iac-eso .IAC-ESO was es tabl i shedin order to facilitate manuscriptpreparation by researchers whosenative language is not Englishand to help edit work intended forinternational academic journals.Quality revision, translation, andediting services are offered by ourstaff, who are native speakers ofparticular languages and who arefamiliar with academic writing andjournal editing in English. 4. Figure Preparation All figures should be clear andcited in numerical order in the text.Figures must fit a oneor two-column format on the journal page:8.3 cm (3.3 in.) wide for a singlecolumn; 17.3 cm (6.8 in.) wide fora double column; maximum height:24.0 cm (9.5 in.). Only use thefollowing fonts in the figure: Arialand Helvetica. Provide all figuresas separate files. Acceptable fileformats are JPEG and TIFF. Pleasenote that files saved in JPEG orTIFF format in PowerPoint lacksufficient resolution for publication.Each Figure file should be smallert han 10 MB in s i ze . Do no tcompress files. A fee is charged fora color illustration or photograph. 5. Online Submission Manuscripts should be submitted toDrug Discoveries & Therapeuticsonline at http://www.ddtjournal.com. The manuscript file should besmaller than 10 MB in size. If forany reason you are unable to submita file online, please contact theEditorial Office by e-mail: [email protected] . Editorial and Head OfficeWei TANG, MD PhDSecretary-in-GeneralTSUIN-IKIZAKA 4102-17-5 Hongo, Bunkyo-kuTokyo 113-0033JapanTel: 03-5840-9697Fax: 03-5840-9698E-mail: [email protected] Cover letter. A cover letter fromthe corresponding author includingthe following information musta c c o m p a n y t h e s u b m i s s i o n :name, address, phone and faxnumbers, and e-mail address of thecorresponding author. This shouldinclude a statement affirmingthat all authors concur with thesubmission and that the materialsubmitted for publication hasnot been previously publishedand is not under considerationfor publication elsewhere and astatement regarding conflictingfinancial interests.Authors may recommend upto three qualified reviewers otherthan members of Editorial board.Authors may also request thatcertain (but not more than three)reviewers not be chosen.The cover letter should besubmitted as a Microsoft Word(.doc) file (smaller than 1 MB) atthe same time the work is submittedonline. 6. Accepted Manuscripts Proofs. Rough galley proofs inPDF format are supplied to thecorresponding author via e-mail.Corrections must be returned within4 working days of receipt of theproofs. Subsequent corrections willnot be possible, so please ensure alldesired corrections are indicated.Note that we may proceed withpublication of the article if noresponse is received. Transfer of copyrights. Uponacceptance of an article, authorswill be asked to agree to a transfero f c o p y r i g h t . T h i s t r a n s f e rwill ensure the widest possibledissemination of information.A l e t t e r w i l l b e s e n t t o t h ecorresponding author confirmingreceipt of the manuscript. A formfacilitating transfer of copyrightwil l be provided. I f excerptsfrom other copyrighted worksare included, the author(s) mustobtain written permission from thecopyright owners and credit thesource(s) in the article. Cover submiss ions . Authorswhose manuscripts are acceptedfor publication in Drug Discoveries& Therapeu t i c s may submi tcover images. Color submissionis welcome. A brief cover legendshould be submitted with the image. Revised February 2008